Middle click to close groups and tray items

Is it possible to make an application terminate by middle clicking on its tray icon (if one).

Similarly, can middle clicking on a group make all the items close.

I am a heavy user of middle clicking to close (tabs in browser, apps from taskbar etc.). I was wondering if it can be made possible to close a window by middle clicking on the titlebar. I found a few AHK scripts for it, but they were not perfect.